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Superoxide radicals generated by electrons leaked from the ETC are converted to HO by SOD, and the hydroxyl radicals (OH) produced from the Fenton reaction between HO and Fe 2+ attack the long-chain polyunsaturated structure of fatty acids [140]

Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B 12 and folic acid on fracture incidence